Concurrent Session 7 - Matrix

Type II Collagen; Designed to Last a Lifetime?

Timeslot: Saturday, April 29, 2017 - 10:45am to 11:15am


The poor regenerative capacity of articular cartilage may relate to a limited turnover of its collagen matrix. However, the actual degree of collagen turnover in cartilage during life has been unclear. This session will focus on what we can learn from tracing of the radiocarbon (14C), produced by nuclear bomb tests in 1955-1963, which is reflected in all living organisms. Data from human cartilage, both healthy and osteoarthritic, will be presented and give insight into the life-long replacement rate of cartilage collagen.