Malcom Macleod FRCP (Edin), PhD

University of Edinburgh

About

Malcolm Macleod is Professor in Neurology and Translational Neuroscience at the Centre for Clinical Brain Sciences, University of Edinburgh, and Head of Neurological Diseases and Stroke at NHS Forth Valley. After undergraduate medicine (including an intercollated degree in Pharmacology) he trained in Internal Medicine before a PhD in the Butcher lab investigating the neuroprotective actions of FK506. This was followed by post-doctoral work in the Seckl lab defining a neuroprotective role for increased expression of the mineralocorticoid receptor.

While this work continued he completed his training in Neurology, including a pivotal sabbatical year with Donnan at the National Stroke Research Institute, Melbourne, Australia. During this time he began an involvement with stroke clinical trials, and it was in an effort to identify suitable drugs for such clinical trials that he started to develop techniques to allow the systematic review and meta-analysis of data from animal studies.

This led to the founding of the Collaborative Approach to Meta-analysis and Review of Animal Data from Experimental Studies (CAMARADES) in 2005. Since then these approaches have found application in a diversity of models, and the CAMARADES group, under his leadership, have build up considerable expertise in this area. He was on the writing committee for the Landis guidelines, contributed to the Lancet “Waste in Research” series, and is an investigator on the MultiPART program developing structures for multicentre animal studies. He is a member of the UK MHRA Commission for Human Medicines and the UK Home Office Animals in Science Committee, and is co-Chief Investigator of EuroHYP-1, a European RCT of brain cooling for stroke.