Tom Appleton MD, PhD, FRCPC

St. Joseph's Health Care


Dr. Appleton received his PhD in Physiology in 2007 working on osteoarthritis (OA) in the laboratory of Dr. Frank Beier on mechanisms of cartilage damage in post-traumatic OA. He continued to work in OA research while completing his MD, residency in Internal Medicine and fellowship in Rheumatology at Western University, Canada. Using genetic and molecular techniques, his work has identified a signaling axis involving transforming growth factor alpha (TGFa) and chemokine (C-C motif) ligand 2 (CCL2) in early post-traumatic OA and demonstrated the efficacy of targeting this signaling axis in pre-clinical studies. Dr. Appleton’s current research interests include cell-mediated destruction of articular cartilage, inflammatory features of OA and pathophysiology of different OA clinical phenotypes.